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Some patients have natural variations that speed medication metabolism, potentially requiring slightly adjusted timing or dose frequency to maintain therapeutic effect

Testing is ordered based on medical necessity, which typically includes patients with diabetes, thyroid conditions, or liver and kidney concerns

Additional contributors may include a longer duration of obesity, older age, lower adherence to exercise, and possible behavioral factors in the T2DM population [46]

Many patients experience a resurgence of symptoms when stepping up to a higher dose

For instance, administration must occur in a fasted state (at least 2-3 hours post-meal) because elevated insulin and blood glucose can significantly blunt the pituitarys response to secretagogues