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It is influenced by: SCFA production Barrier integrity Microbial diversity Inflammatory tone L-cell receptor sensitivity Inflammatory tone in particular is not always gut-generated

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Apathy related pathology Apathy in AD is most commonly associated with pathological changes of the anterior cingulate cortex (ACC), which include cortical thinning, atrophy, low fractional anisotropy (FA) scores, amyloid accumulation, hypometabolism, and neurofibrillary tangles (Marshall et al., 2006, 2007

Take eight tablets a day with water for optimal results

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