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But once the pituitary responds and IGF-1 rises, the normal IGFBP buffering system still operates on the IGF-1 that is produced

Determining the appropriate clinical trial duration NASH is a chronic disease like diabetes and it is likely that any intervention will need to be potentially life-long, though this may depend on the drug's mechanism of action

Frias JP, Hsia S, Erichsen L, et al