Dopo ulteriori studi, la semaglutide stata riformulata con una dose pi alta e approvata dalla FDA nel 2021, e pi di recente dallEMA in Europa e lAIFA in Italia, come Wegovy per il trattamento dellobesit
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McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H (2012) The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
Besides, only in a minority of patients, elevation of pancreatic or liver enzymes was seen, resulting in no pancreatitis and/or cholelithiasis occurrence, which was also verified in a recent meta-analysis showing that treatment with GLP-1-RAs is not associated with increased risk for acute pancreatitis, renal failure, or malignant neoplasms [43]
Patients often experience preferential loss of visceral fat, which provides additional cardiovascular and metabolic benefits beyond weight reduction