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Subsequent work has largely validated the hypothesis, ie, trials of hemodynamic interventions have yielded disappointing or deleterious results, 2-4 whereas trials with beta-blockers, mineralocorticoid receptor antagonists (MRAs), and neprilysin inhibitors supported a role for neurohormonal mechanisms
Skin that once held moisture effortlessly becomes chronically dehydrated despite adequate water intake
In an acute study, delayed-release delivery to the gut cut energy intake at test meals by about 18% in healthy-weight men [1]
Post-menopausal use, while off-label, is supported by mechanistic logic and substantial compounding-pharmacy clinical experience
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