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Receptor autophosphorylation, downstream phosphorylation of IRS-1 and Shc, and activation of PI3K and MAPK occur with similar kinetics to native IGF-1 once the ligand reaches the receptor
Some newer agents act not only on the GLP-1 receptor but also on additional targets, such as the glucose-dependent insulinotropic polypeptide (GIP) receptor
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The effects of GLP-1RAs on prostate cancer risk Preclinical studies have demonstrated that GLP-1RAs are capable of inhibiting the proliferation of prostate cancer cells in both in vivo and in vitro experiments, thereby suggesting potential preventative effects [36]
2013;216(1):T115
