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By stimulating these two hormone pathways simultaneously, tirzepatide regulates appetite, slows gastric emptying, improves insulin sensitivity, and promotes fat mobilization, producing greater, more sustained weight loss than GLP-1-only therapies like semaglutide
Both excess and deficiency of THs quickly lead to significant changes in body weight: in hypothyroidism, total body weight can increases even by one-third, while in hyperthyroidism, it can decrease by approximately 15%
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Some need far less insulin and some get off it altogether
