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Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)

Considering that obesity is a chronic and recurrent disease and that shared decision-making needs to be encouraged for managing the condition, the 5 As strategy (ask, assess, advise, agree and assist) is recommended

Staying hydrated supports digestion and helps manage common side effects such as constipation. Avoid: Sugary drinks and excessive fruit juice (limit to 150ml per day)

This gives people who prefer to avoid needles a legitimate alternative, though dosing schedules can differ from injectable versions

Researchers should consider the trial design, reported frequency, severity, discontinuation patterns and any dose-related observations