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Third, individual variation is substantial: patients with severe insulin resistance or significant mitochondrial dysfunction may respond at lower doses than metabolically healthy athletes
This means that if we try to optimize a non-convex function, we may get stuck in a local minimum and miss the global minimum, which is the optimal solution we are looking for
Fatigue, weakness, tingling, brain fog, and mood changes can be signs of low B12, yet they're often mistaken for stress or overwork
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