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Our data are in agreement with a recent report using the same antibody, the specificity of which is suggested by the loss of immunoreactivity in islets from Gcgr / mice [20]
Using a Large Genetic Biobank The research team worked with retrospective data derived from the Million Veterans Program, created by the VA and considered the largest genetic biobank in the world
Exendin 939 does not affect TRPV1 activation via protons, suggesting its mode selectivity As the inhibitory effect of exendin 939 on CAP-induced activation of TRPV1 was confirmed, its effect on proton-induced activation of TRPV1 was also tested via patch-clamp recordings and calcium imaging
Notably, fiber photometry also revealed that systemic administration of GLP-1 [149] and liraglutide [148] does not affect the activity of ARC AgRP/NPY neurons, emphasizing how findings from patch-clamp electrophysiology experiments on hypothalamic slices can differ from the situation in vivo
DiStefano MJ et al
