For the past few decades, studies looking at obese humans that were randomized to compare very low carbohydrate diets and higher carbohydrate diets have consistently demonstrated greater initial weight and body fat losses with the low carbohydrate diets designed to induce nutritional ketosis (1)
They must be conjugated to carnitine by carnitine palmitoyltransferase I (CPT-I) on the outer mitochondrial membrane to form acylcarnitine, transported across the inner membrane by carnitine-acylcarnitine translocase (CACT), and then released by carnitine palmitoyltransferase II (CPT-II) on the inner membrane for entry into beta-oxidation
The FDA officially removed tirzepatide from the shortage list in December 2024 and removed semaglutide in February 2025
Awards of research fellowships to NB from the CSIR, New Delhi, and SK from UGC, New Delhi, are greatly acknowledged
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