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Science 303 , 495499 (2004)

(2012) demonstrated: Statistically significant reductions in visceral adipose tissue of approximately 1518% over 26 weeks compared to placebo Meaningful increases in IGF-1 levels Improvements in triglyceride profiles in some patient subgroups Effects were partially reversed upon discontinuation, suggesting that sustained benefit requires ongoing therapy The consistency of the VAT reduction finding across multiple trials is what anchors tesamorelin's clinical utility

doi: 10.1016/j.molcel.2022.02.033 47 YangZYanCMaJPengPRenXCaiSet al

It really comes down to being ok staying exactly where you are and not trying to improve your health and your life and setting yourself up for being able to walk 12 week GLP-1 check in with @tryeden

e-Pub 2026