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This pathological process clinically results in progressive muscle weakness and atrophy, spasticity, respiratory failure, and finally death [1]

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The authors investigated the biological significance of SLC25A45 in vivo

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The Phase 2 trial used 2mg as the starting dose, and it is the lowest dose in the standard published titration: 2mg, then 4mg, then 8mg, then 12mg, each held for 4 weeks

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