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Oval cell hyperplasia can be observed following severe hepatotoxic injury and treatment with hepatocarcinogens

Sikiric P, Gojkovic S, Krezic I, Smoday IM, Kalogjera L, Zizek H, Oroz K, Vranes H, Vukovic V, Labidi M, Strbe S, Baketic Oreskovic L, Sever M, Tepes M, Knezevic M, Barisic I, Blagaic V, Vlainic J, Dobric I, Staresinic M, Skrtic A, Jurjevic I, Boban Blagaic A, Seiwerth S

The SAH hydrolase reaction is reversible, so methylation can remain blocked when homocysteine and especially adenosine are not adequately metabolized or removed

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