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An early study showed that 250 M acetyl-l-carnitine did not affect axon regeneration but significantly reduced the rate of death of neurons from the DRG of aging rats, suggesting its neuroprotective action [14]

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In one program, a separate NNMT inhibitor reduced 1-methylnicotinamide levels and improved insulin sensitivity and glucose tolerance in DIO mice, with these effects absent in NNMT-knockout animals

10.1007/s00125-009-1637-8 69 TianJ.WenH.ZengL.JiangM.WuF.LiuW.et al (2013)