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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint
"Governance in Vanuatu: In Search of the Nakamal Way"
Decreased perfusion compromises oxygen and nutrient delivery, leading to ischemic injury of cochlear and auditory nerve cells [6-10]
discussion 260-268
In the same research, it also reduced markers of apoptosis (programmed cell death) in those cells, keeping them alive and functional longer
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