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Under physiological conditions plasma glutamate concentration, 10-20uM, is limiting for GDH flux supplying TCA intermediates while plasma glutamine concentration, 600uM, is not [2]
The study incorporated a range of demographic and health-related factors, including age, sex, body mass index, smoking, alcohol use, physical activity, chronic disease burden and cardiovascular disease
Furthermore, meta-regressions demonstrated that publication year significantly affected the associations between homocysteine, cysteine, and ASD, and the association between vitamin B9 and ASD was affected by age