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(PubMed) Wilson CP, Ward M, McNulty H, et al

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Therapeutic approaches aimed at modulating lactate metabolism have demonstrated some potential in regulating ferroptosis in neurodegenerative diseases, IRI and sepsis

In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis ( 102 prevented erastin-induced ferroptosis evidently in a dose-dependent manner ( Figure 8A ), even when the concentration of erastin reached to 100 M ( Figure 8B )