The most successful treatments currently available include glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), exemplified by semaglutide (approved in 2017, $19.9 billion sales in 2023) 3 and tirzepatide (approved in 2022, $5.3 billion sales in 2023) 4
Because standard capsules and powders must pass through the harsh environment of the stomach, high doses can irritate the gut lining
Charlson ME, Pompei P, Ales KL, MacKenzie CR
However, the inactive ingredients, formulation process, and final product characteristics may differ from branded versions
The triple receptor activation made biological sense in a way that other options hadnt