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Specifically, the relationship between incremental costs and benefits between semaglutide 2.4 mg and the no treatment arm allowed to calculate the ICER for the base case scenario, measured as /QALY, considering as target population patients with obesity and concomitant MASH (F3), in MASLD patients without diabetes
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The main considerations: seizure risk with bupropion in vulnerable patients, blood pressure effects (bupropion can raise BP slightly), and overlapping appetite suppression that can drive intake low