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Labeling across this class advises against concomitant use with other GLP-1 receptor agonists, and stacking a residual supply of one medication onto a newly started one is the most predictable way to turn a routine transition into a serious adverse event

Co-agonism showed, on murine models, the capability to improve insulin secretion and sensitivity in a weight-dependent and weight-independent manner, probably through its action on nutrient metabolism (49, 50), preventing their accumulation and thus making these organs actively involved in metabolism with an improvement in insulin sensitivity and WL, yielding long-lasting effects

And now, now it doesn't work as well

These effects tend to be manageable by starting at a low dose and increasing gradually

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