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Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures

Very rare : A medical eye condition called non-arteritic anterior ischaemic optic neuropathy (NAION) this may cause gradual vision loss in one of your eyes

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While testers noted that it has more of an artificial sugar taste, it wasnt something that necessarily deterred them