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The absence of human data means researchers using KLOW must establish their own safety protocols, justify dosing extrapolations from animal models, and navigate heightened institutional review scrutiny
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This observation is consistent with the relatively minimal effect of BETP on signaling of the potent GLP-1R endogenous agonist GLP-1, compared to the weaker agonist GLP-1(9-36)amide, whose effects are potentiated by BETP ( 21 )
These often improve with gradual dose titration
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