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In central sensitization, the spinal cord and brain amplify incoming signals regardless of their original intensity
10.1182/blood-2009-09-245977 135 SatoY.MizuguchiT.ShigenagaS.YoshikawaE.ChujoK.MinakuchiJ.et al (2012)
Can Semaglutide GLP-1 be taken long-term
On GLP-1 medications, you're fighting three dehydration mechanisms simultaneously: Reduced thirst signaling (central appetite suppression affects thirst centers) Reduced fluid intake with meals (nausea makes drinking unpleasant) Ongoing fluid loss from glycogen metabolism during weight loss The result is chronic mild dehydration in a substantial portion of patients during titration
The following schedule applies across all Child-Pugh classes, with frequency adjusted upward for higher severity
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