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Contraception note for GLP-1/GIP: The dual-agonist can reduce the effectiveness of oral hormonal contraceptives during dose escalations
The Semaglutide cohort compared to the non-GLP-1RA anti-diabetes medications cohort included more women, had a higher prevalence of problems with lifestyle, obesity, obesity-associated comorbidities, mental disorders, and substance use disorders
Plus, many patients report that cravings for unhealthy foods drastically diminish, helping them stick to a healthier lifestyle
The proposed mechanism involves MMP-1, a specific matrix metalloproteinase
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