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Specifically, the combination of MCT4 inhibition with ferroptosis inducers not only depletes lactate accumulation but also enhances CD8+ T cell infiltration and ferroptosis-driven ICD, thereby synergistically improving checkpoint blockade efficacy (111)
Importantly, oxidative damage caused by the production of ROS has been linked to the etiology of different types of human cancer [23, 36]
(2000) Case-control study of plasma folate, homocysteine, vitamin B12, and cysteine as markers of cervical dysplasia
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