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According to the Summary of Product Characteristics (SmPC), the most commonly reported adverse effects include: Nausea and vomiting (very common) particularly during dose escalation Diarrhoea or constipation (very common) affecting bowel regularity Abdominal pain and discomfort (common) often mild to moderate Reduced appetite (very common) contributing to weight loss Dyspepsia (common) indigestion or heartburn Injection site reactions (common) such as redness or irritation Fatigue (common) tiredness or lack of energy These gastrointestinal symptoms typically diminish over time as the body adjusts to the medication

Updated This article was originally published on February 26, 2026, and has been updated to reflect Novo Nordisks voluntary dismissal of all claims asserted in its case against Hims & Hers without prejudice.

Metabolic Stuckness: If you have underlying insulin resistance or PCOS , it may take a few extra weeks for the medication to unclog your metabolic pathways and start the fat-burning process

The Y97F mutation increased the catalytic efficiency of the l-cysteine -lyase activity by 11-fold (Table 1)

CinFina Pharma, Inc