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These synaptogenesis promotion properties make Dihexa uniquely valuable for cognitive enhancement research, understanding the molecular basis of memory formation, and developing therapeutic approaches for conditions involving synaptic loss such as Alzheimer's disease and age-related cognitive decline

Due to the importance of folates in DNA precursor metabolism, a negative effect of folate depletion on S phase enzymes was postulated

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Homocysteine, through activation of NMDA receptors, induces Ca +2 , leading to excitotoxicity, astrocyte activation with release inflammatory mediators, and matrix metalloproteinase (MMP) activation with subsequent BBB injury and microvascular inflammation (Kamat et al