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People with a history of certain thyroid cancers, pancreatitis or gastrointestinal conditions like gastroparesis are also advices to avoid GLP-1s

Practiced safely, intermittent fasting can help regulate insulin levels, improve fat metabolism, and simplify calorie control

Research focused on localized gut issues (like intestinal permeability or inflammation) may respond well to standard doses because the peptide is acting directly on the target tissue during its transit

At the same time, the equity questions are just as important as the efficacy curves: Who will actually have access to orforglipron once it is approved

Thyroid C-cell tumours have been observed in rodent studies with GLP-1 receptor agonists, though the relevance to humans remains uncertain