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Madigan CD, Graham HE, Sturgiss E, et al

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To rule out whether this effect of histamine on exacerbating colitis worked through either of the other gut-expressed histamine receptors, we performed the Ox-induced colitis model in H1R/H2R double-knockout mice ( H1R / H2R / ) and found similar weight loss, disease activity index scores, and histology scores between H1R / H2R / and control WT mice (Supplementary Figure S4)