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You shouldnt take semaglutide if: You or a family member has a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)

doi: 10.1016/j.celrep.2022.111314 149 NakajimaM.ArimatsuK.KatoT.MatsudaY.MinagawaT.TakahashiN.et al

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It is inexpensive, widely available, extremely well-studied, and has a favorable safety profile spanning decades of use