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As with any peptide not yet FDA-approved, long-term safety data remains limited

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Preclinical data suggests that chronic pain may cause significant changes in hippocampal plasticity, including a reduction of new neurons in the hippocampus (a portion of the brain related to learning, memory, mood regulation, and stress response.) It has previously been believed that a person is born with a finite number of neurons which will deteriorate over time

The vast majority of information comes from in-vitro and animal studies