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Long-term use of metformin (for type 2 diabetes) or proton pump inhibitors can also deplete B12 levels over time

Researchers study this compound to understand how blocking NNMT activity affects related metabolic pathways at the cellular level

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[4] In differentiated 3T3-L1 mouse adipocytes, 5-Amino-1MQ lowered intracellular 1-MNA in a concentration-dependent manner with an EC 50 of 2.3 1.1 M (R = 0.94)

With oral supplements, it can take weeks to notice an improvement