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BH: Methodology, Writing original draft, Writing review & editing, Investigation
Triggers of elevated ceramide levels comprise hyperosmotic shock [122], secreted sphingomyelinases (SMases) during inflammation [125], sepsis [126] or severe coronavirus disease 2019 (COVID-19) [127], Clostridium perfringens epsilon toxin [128], and platelet-activating factor [129]
Aggregates can change pharmacological behaviour, reduce effective bioavailability or contribute to antibody formation
[39] [40] [204] Notably, amphetamine and trace amines possess high binding affinities for TAAR1, but not for monoamine autoreceptors
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