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Several garlic-derived organosulfur compounds, including S-allylcysteine and ajoene, have been found to inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), a critical enzyme in the cholesterol biosynthesis pathway (39, 40)

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Several changes can occur at the same time: Progesterone fluctuations can disrupt sleep quality Poor sleep can increase stress signaling in the body Higher stress sensitivity can amplify nausea or digestive discomfort GLP-1 medications commonly cause temporary gastrointestinal side effects during dose increases

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There are several GLP-1RAs and one GIP/GLP-1RA available for the management of T2DM and/or obesity