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Under stress, MOTS-C translocates to the nucleus for direct gene regulation a dual-compartment mechanism unique among metabolic peptides
For ACF, the existing strategies mainly include chemoprevention (such as the use of drugs like aspirin and celecoxib), dietary modification (increasing fiber intake and reducing the consumption of red meat and fat), as well as preventing the occurrence and development of colorectal cancer through endoscopic monitoring and the resection of high-risk lesions 49,50
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Adipocyte nuclei were identified based on the expression of established markers ( Lipe , Plin4 , Plin1 and Pparg ) and filtered for reclustering using Seurat
Interpretation of the cardiovascular actions of native GLP-1 requires consideration that carboxy- terminal fragments, such as GLP-1(936) and GLP-1(2836), the latter generated from neutral endopeptidase-mediated proteolytic cleavage, retain biological activity in the cardiovascular system through mechanisms independent of the canonical GLP-1R
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