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16 A Unique Mechanism Whats particularly intriguing is how allulose triggers GLP-1 release

IRC is best suited for patients with: Bleeding internal hemorrhoids (Grade I or II) Mild prolapse that returns spontaneously Symptoms such as rectal bleeding, itching, or minor discomfort It is not recommended for external hemorrhoids or more advanced cases where surgical intervention may be more appropriate

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While little is known about the role of this GLP-1R population, a function of the Brunner's glands is to secrete mucus to lubricate the intestinal wall and, as GLP-1 has been suggested to be a positive regulator of gut-barrier function, GLP-1 may act on these glands to increase mucus secretion, thereby decreasing inflammation and protecting against intestinal damage

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