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In addition to glutamate receptor modulation by agonists, antagonists, and negative allosteric modulators, drugs or agents can be developed that can inhibit glutamate release, facilitate the clearance of glutamate by excitatory amino acid transporters, and modulate the voltage gated Na + channels that are involved in glutamate regulation (Fig

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Concerto, C., Chiarenza, C., Di Francesco, A., Natale, A., Privitera, I., Rodolico, A., Trovato, A., Aguglia, A., Fisicaro, F., Pennisi, M., Bella, R., Petralia, A., Signorelli, M