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Increased oxidation of FFAs in aortic endothelial cells leads to increased peroxide production by the mitochondrial ETC, which activates ROS and inactivates two important antiatherosclerotic enzymes: prostacyclin synthase and eNOS [58]

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AM833 is a novel agonist of calcitonin family G protein-coupled receptors: Pharmacological comparison with six selective and nonselective agonists