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As activation progresses, M1 macrophages further enhance glycolytic flux, engage in de novo fatty acid synthesis, and activate the pentose phosphate pathway (PPP)

In the strain harboring the L-carnitine biosynthetic pathway (labeled TML2Car), the supplementation of 100 M TML resulted in a fluorescence response of the L-carnitine biosensor

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For peripheral vascular disease, where reduced blood flow to the extremities causes pain and tissue damage, this collateral activation mechanism could theoretically provide meaningful benefit

The experiment was divided into a normal control group, a DSS model group, and a DSS+IGF-1 LR3 treatment group (with doses of 0.1mg/kg, 0.5mg/kg, and 1mg/kg, respectively, orally administered daily), and treated continuously for 7 days