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Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, or mood changes, hunger, weakness and feeling jittery

The interaction between GLP-1 medications and substances of abuse has not been systematically studied

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People taking psychiatric medications Several psychiatric medications interact with vitamin B6 metabolism

If the drug: Has multiple peaks in PK profile Shows flip-flop kinetics or irregular absorption Has high accumulation or delayed onset Requires partial AUCs or special PK handling In these cases, follow Health Canadas traditional MR guidance (TGD or BE standards)