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The concern about semaglutide specifically traces back to a 2021 meta-analysis published in the Endocrine Journal

As previously discussed, neurodegenerative and autoimmune disorders such as AD, MS, and PD are associated with reduced GSH concentrations in the brain making supplemental GSH an attractive therapy if the limitations in delivery can be overcome (Smeyne and Smeyne, 2013)

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Loss of lean mass or functional decline suggests that nutritional support is inadequate relative to weight loss rate

Diabetes Care 21 , 14141431 (1998)