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B12 supplementation in elderly patients with confirmed deficiency typically takes two main forms in the UK: Oral tablets (cyanocobalamin) Intramuscular injections (hydroxocobalamin, the standard form in the UK) NICE Clinical Knowledge Summary guidance recommends investigating B12 deficiency in older adults presenting with unexplained anaemia, neuropathy, cognitive impairment, or glossitis
In this case, the methyl group does not come from methylcobalamin, but from TMG, which turns it into dimethylglycine (DMG)
The NHS notes that adults need only around 1.5 micrograms a day, which a normal mixed diet covers with ease
There is a limit to the amount of medicine that can be delivered comfortably
Cyanocobalamin is a dietary supplement that contains vitamin B12 used to treat patients with vitamin B12 deficiency that can lead to other conditions
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