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Anyone participating in a clinical trial who experiences persistent or severe gastrointestinal symptoms, unexplained abdominal pain (which may indicate pancreatitis or gallbladder disease), signs of dehydration, or other concerning symptoms should contact their supervising healthcare team promptly

The focus remains on making long-term, sustainable adjustments to diet and activity levels

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Diabetes was defined by fasting glucose 7.0 mmol/L, HbA1c 6.5%, or the use of anti-diabetic medications