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Interestingly, while ROSE-010 effects seem to be dose dependent in previous studies, we did not find a correlation between the amount of change in GLP-1 and amount of IBS-SSS reduction (9, 10)

Obesity 31:703715 Wadden TA, Chao AM, Machineni S et al (2023) Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial

Estradiol has been related to the modulation of appetite and the balance of glycemia, having a crucial role in the maintenance of the metabolic homeostasis and body weight (Rubinow, 2017)

I dont think weve ever seen anything like this, says Andriola

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