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Rapid weight loss with GLP1 receptor agonists can come at the cost of skeletal muscle, potentially undermining metabolic and functional outcomes
Clin Exp Immunol 185(1):121 Trzaskalski NA, Fadzeyeva E, Mulvihill EE (2020) Dipeptidyl peptidase-4 at the interface between inflammation and metabolism
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The downstream consequences include enhanced glucose uptake into skeletal muscle independent of insulin, increased fatty acid oxidation, and suppression of inflammatory signaling