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Although the phase I results were promising, with some patients demonstrating improvements in left ventricular structure and function, the subsequent CUPID2 trial revealed that AAV1/SERCA2a therapy failed to reduce HF recurrence or delay terminal events

Instruct patients using ZEPBOUND vials to use a syringe appropriate for dose administration (e.g., a 1 mL syringe capable of measuring a 0.5 mL or 0.6 mL dose) and always use a new syringe and needle for each injection

The participants of the phase 2 trial used the medication for 48 weeks

Receptor pharmacology is largely conserved across species for GHS-R1a, but dose-response relationships, receptor density, and feedback dynamics differ

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