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Aggregating data from Table 3 reveals consistent cross-barrier alterations in cytokine levels in both CSF and peripheral blood across different clinical stages (first-episode/FES, acute/ASZ, and chronic/CSZ), which hold clinical translational significance: 1)

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The overabundance of carbs or inadequate carbohydrate oxidation results in an elevation of fat accumulation via the de novo lipogenesis pathway [95]

Retatrutide is an investigational triple incretin receptor agonist administered as a weekly subcutaneous injection in clinical trials, with dose escalation used to improve tolerability

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