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Even at doses far exceeding the standard 10 mcg/kg range (scaled to human-equivalent doses of roughly 200-800 mcg/day for a 70-kg adult), researchers have not observed pathological angiogenesis, tumorigenic signaling, or behavioral toxicity 1

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Moreover, PAS* has immune signaling capacity and induced cytokines IL-1, IL-6, IL-8, IL-10 and TNF- production in human peripheral blood mononuclear cells (PBMCs) [48]