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In summary, genetic loss of PTPN11 caused deeper metabolic and signaling rewiring than pharmacologic inhibition did, likely due to clonal selection and/or the complete loss of phosphatase-independent molecular adapter functions of SHP2, and may not reflect the phenotype induced by allosteric inhibition
If hair preservation is a primary concern and moderate weight loss is acceptable, discussing these alternatives with your prescriber is reasonable
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Nucleic acids research
VA researchers are studying whether the GLP-1 receptor agonist may affect parts of the brain involved in reward, potentially offering a new treatment option for veterans with moderate or severe alcohol use disorder if proven safe and effective
